Figure 2.

BANs of differentially expressed genes in common between cell lines. The lists of common genes between both colon cancer cell lines, between both breast cancer cell lines, and among the other three cell lines studied (representative of pancreatic cancer, leukemia and osteosarcoma) were used to construct BANs with the Pathway Architect software. Expanded networks were constructed for each list - (a) colon cancer, (b) breast cancer and (c) the other three cell lines - by setting an advanced filter that included the categories of binding, expression, metabolism, promoter binding, protein modification and regulation (see legend). Only proteins are represented. Overlapping of the expression levels was also performed (red for overexpressed genes and green for underexpressed genes; translucent shading represents genes that were not in the list and were added by the program from the interactions database). The BANs show some node genes that were studied further (those with arrows pointing to them).