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Intervention of the miRNA pathway can alter the sensitivity of PANC1 cells to cyclophosphamide, which is activated to cytotoxic agents by CYP3A4. Note that drug sensitivities are significantly (P < 0.001; two-way ANOVA) different between the absence and presence of VD3, between VD3 only and VD3 combined with ketoconazole, and between pS-miR-27b/mmu-miR-298 and pS-Neg treatments (n = 3 at each concentration), respectively.
