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pKi and Hill slope values obtained for ghrelin, MK-677, GHRP-6, and L-692,585 competing with 125I-ghrelin binding to the ghrelin receptor
The use of an F test revealed that data were best fit to one-site competition curves. In each instance, the Hill slope obtained was not significantly different from unity. Data are presented as mean ± S.E.M.
| Ligand | pKi | Hill Slope |
|---|---|---|
| Ghrelin | 8.97 ± 0.27 | 0.59 ± 0.41 |
| GHRP-6 | 7.51 ± 0.71 | 0.52 ± 0.63 |
| MK-677 | 8.14 ± 0.08 | 0.67 ± 0.49 |
| L-692,585 | <6.00 | Not fitted |
