Skip to main content
. 2009 Aug 21;112(1):59–67. doi: 10.1093/toxsci/kfp201

FIG. 2.

FIG. 2.

Concentration-response of 3MI-induced DNA damage in NHBE cells. Four-hour incubation with increasing concentrations of 3MI (gray bars) and doxorubicin (black bars) produced a concentration-dependent increase in DNA damage (average OTM). Thirty-minute pretreatment with ABT (gray striped bar) inhibited the DNA damage response to 3MI treatment. Treatment with ABT alone (black dotted bar) did not significantly increase the levels of DNA damage as compared to vehicle (0.5% DMSO)-treated control (white bar). *p < 0.05 compared to vehicle-treated control, ‡p < 0.05 compared to 10μM 3MI.