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p53 nuclear localization and phosphorylation increase in response to submicromolar 3MI exposure. NHBE cells were exposed to a range of 3MI concentrations or vehicle for 1 h. p53 nuclear localization was determined by immunohistochemistry (A and B). White arrows (B) indicate those cells with complete p53 nuclear localization. Total p53 and p53 phosphorylated at serine 20 were determined by Western blot (C). *p < 0.05 compared to vehicle-treated control.
