Table 1.
Charge of atoms in different chemical groups calculated with Material Studio®.
| Polymer | Group | Charge/electron |
|---|---|---|
|
Very low hydrolytic activity (with low charge and protecting groups) | ||
| Polyolefin | -C*H2-CH2- | −0.11 |
| Polyether | -C*H2-O-CH2- | 0.054 |
| Polysulfone (aromatic) | -C*-SO2-C- | 0.073 |
| PDMS | -Si*-O- | 0.62 |
|
Low hydrolytic activity (due to conjugate structures) | ||
| Polycarbonate | -O-C*O-O- | 0.72 |
| Polyimide | -(CH2-C*O)2-N- | 0.45 |
| Polyurethane | -O-C*O-NH-C- | 0.63 |
| Polyester (aromatic) | -C*O-O-C- | 0.60 |
| Polyamide | -C*O-NH-C- | 0.45 |
|
High hydrolytic activity (due to high charge and steric effects) | ||
| Polyanhydride | -(CH2-C*O)2-O- | 0.56 |
| Polyorthoester | -R-C*-(O-R)3 | 0.49 |
| Polyketal | -R2-C*-(O-R)2 | 0.32 |
| Polyester (aliphatic) | -C*O-O-C- | 0.56 |