Figure 2.

(Top left) Latency to locate hidden platform in the spatial water maze across six training trials and 30 d of retention. A significant impairment in acquisition was observed among aged animals (an effect also seen in the search strategy exhibited during a short-term probe test, top right). A significant deficit in 30-d retention was observed in old relative to young mice after six training trials. Brackets indicate standard errors. (Bottom left) Latency to locate hidden platform in the spatial water maze across 11 training trials and 30 d of retention. Both young and old animals exhibited comparable performance after 11 trials (a pattern also seen in the search strategy exhibited during a short-term probe test, bottom right). After 11 training trials, no differences in retention between young and old animals were observed after 30 d. Brackets indicate standard errors.