Figure 10. Reduction of the protective effect of gliclazide on H₂O₂-induced cell death by D600.

Apoptotic islet cells were detected by active caspase3. Cells were incubated for 5 hours with 10 μM gliclazide with or without 100 μM D600. During the last 60 minutes, H₂O₂ was added as indicated. For comparison, the effects without gliclazide treatment are shown. n is given within each bar. ***P ≤ 0.001.