Figure 3. Effect of H₂O₂ on [Ca²⁺]_c in Sur1^–/– and WT β cells.

Time of addition of 10 μM H₂O₂ is denoted by horizontal bars. (A) WT β cells. Shown is 1 of 12 experiments with similar results in which oscillations stopped; in 7 experiments (not shown), oscillations persisted in the presence of H₂O₂. (B and C) Sur1^–/– β cells. Shown are 2 representative experiments of 19: (B) 1 experiment with oscillations in the presence of H₂O₂, and (C) 1 experiment in which a plateau above basal values was reached.