Skip to main content
. 2009 Oct 5;119(11):3450–3461. doi: 10.1172/JCI38432

Figure 11. Treatment with aspirin prevents TRALI.

Figure 11

(A–C) Extravascular lung water (A), lung vascular permeability (EVPE) (B), and survival curves (C) in mice treated with aspirin (ASA; 100 μg/g, i.p.) or vehicle (veh) (DMSO; 1 μl/g, i.p.) 30 minutes prior to LPS (0.1 mg/kg, i.p.) and again 2 hours prior to MHC I mAb (0.5 mg/kg) or control (PBS). Data were obtained 2 hours after injection of MHC I mAb or PBS. **P < 0.05 vs. other groups. (D) Plasma thromboxane B2 levels in TLR4d and WT mice challenged with LPS (0.1 mg/kg, i.p.), MHC I mAb (0.5 mg/kg), and ASA (100 μg/g). *P < 0.05 vs. WT plus no LPS; **P < 0.05 vs. all other groups, †P < 0.05 vs. all other groups.