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. 2009 Oct 5;119(11):3450–3461. doi: 10.1172/JCI38432

Figure 8. Neutrophil depletion protects mice from 2-event TRALI and from platelet sequestration in the lungs.

Figure 8

Platelet depletion does not affect lung neutrophil sequestration. (A) Extravascular lung water and EVPEs in BALB/c WT mice pretreated with either Gr-1 mAb (250 μg, i.p.) or isotype control (cont) and administered i.t. LPS (0.1 mg/kg), followed by MHC I mAb (4.5 mg/kg). Vertical lines indicate mean ± SD. **P < 0.05 vs. isotype control. (B) 51Cr-platelet counts (whole lung/100 μl blood) in WT control mice and mice given i.t. LPS (0.1 mg/kg) with or without MHC I mAb. The far right bar represents mice pretreated with Gr-1 mAb. **P < 0.05 vs. all other groups. (C) Whole lung MPO (units/ml lung supernatant) measurements. LPS (0.1 mg/kg, i.t.), MHC I mAb (4.5 mg/kg), antiplatelet serum (25 μl, i.p.) were used. Iso, isotype control mAb; Con, control rabbit serum; NS, normal saline. **P < 0.05 vs. normal saline; †P < 0.05 vs. control serum.