Figure 3. Induction of IFN-β by activation of TLR4, but not TLR3, is abnormal in Hfe KO macrophages.

WT and Hfe KO macrophages were stimulated with (A) 100 ng/ml LPS or (B) 10 μg/ml poly(I:C) for 6 hours (n = 3 per group). Supernatants were collected and analyzed by ELISA for IFN-β. Data represent mean ± SD. Similar results were obtained in 2 separate experiments. *P = 0.026; **P = 0.039.