Table 1. miRNome analyses in cancers.
miRNA expression profiles from clinical specimens or cancer cell lines are listed according to tumor types. Profiling methods are bead based flow cytometric profiling (bead), qRT-PCR, microarray of miRNA chip (array), membrane spotted array (membrane), cloning, or miSAGE (serial analysis of gene expression of miRNA). miRNAs of notable change are indicated
| Tumor type | Profiling method |
miRNAs deregulated in tumor | note | ref | |
|---|---|---|---|---|---|
| up-regulated | down-regulated | ||||
| breast cancer | bead | classification of breast tumors into five sub-types |
(93) | ||
| breast tumor | qRT-PCR array |
miR-21 | (165) | ||
| breast cancer | array | classification according to ErbB2/ER status |
(158) | ||
| breast cancer | array | miR-21 | miR-125b, -145 | clinicopathologic features | (185) |
| prostate cancer | array |
let-7c, miR- 125b, miR-145 |
(186) | ||
| prostate cancer | membrane | classification according to androgen dependency |
(66) | ||
| prostate cancer | array | (158) | |||
| pancreatic cancer |
array | miR-21, -221, -222, -181a, -181b, - 181d, -155 |
vs. chronic pancreatitis and normal tissues |
(187) | |
| pancreatic cancer |
array | miR-196a | miR-217 | pancreatic ductal adenocarcinoma vs. chronic pancreatitis and normal tissues |
(160) |
| pancreatic cancer |
qRT-PCR of pre- miRNA |
let-7i, miR-100, - 155, -221, -301, - 21,-181a, -125b, - 212, -376a |
miR-375 | pancreatic adenocarcinoma, paired benign tissue, normal pancreas, chronic pancreatitis |
(188) |
| pancreatic tumor |
array | miR-103, -107, - 23a, -26b, -342, - 192, -204, -211, -21 |
miR-155 | endocrine tumors vs. acinar cell carcinoma |
(189) |
| lung cancer | array | miR-21, -205 | miR-126* | clinicopathological features |
(190) |
| ovarian cancer | array | miR-200a, -141 | miR-199a, -140, -145, -125b1 |
clinicopathological features |
(191) |
| cervical cancer | array | vs. Drosha overexpression | (95) | ||
| uterine leiomyoma |
array | let-7, miR-21, -23b | clinicopathological features (tumor size, race, etc) |
(192) | |
| hepatocellular cancer |
array | miR-21 | (134) | ||
| hepatocellular cancer |
array | miR-221 | let-7a, miR-122a | vs. liver cirrhosis | (193) |
| hepatocellular cancer |
array | miR-224, -18 | miR-199a, - 199a*, -200a |
(194) | |
| thyroid cancer | array | miR-30d, -125b, -26a, and -30a- 5p |
anaplastic thyroid carcinomas vs. normal tissues |
(67) | |
| thyroid cancer | array | miR-197, -346 in FTC relative to FA |
follicular thyroid carcinoma (FTC) vs. follicular adenoma (FA) |
(195) | |
| thyroid cancer | array | miR-221, -222, - 181b |
papillary thyroid carcinoma vs. normal tissues |
(159) | |
| thyroid cancer | array | miR-221, -222, - 146b |
papillary thyroid carcinoma vs. normal tissues |
(100) | |
| colorectal cancer |
array | miR-25, -92 in MSS relative to MSI-H |
microsatellite stability (MSS) vs. high microsatellite instability (MSI-H) |
(196) | |
| colorectal cancer |
qRT-PCR | miR-31, -96, -135b, -183 |
miR-133b, -145 | miR-31 according to cancer stage |
(197) |
| colorectal cancer |
cloning miSAGE |
(17) | |||
| pituitary adenomas |
array | miR-26a, -149 | miR-21, -141, - 144 |
clinicopathological features |
(198) |
| neuroblastoma | qRT-PCR | neuroblastoma subtypes | (69) | ||
| glioblastoma | array | miR-221. -10b | miR-128, -181b, -181a |
(199) | |
| leukemia | bead | miR-128a, -128b in ALL compared with AML |
let-7b, miR-223 in ALL compared with AML |
acute lymphoblastic leukemia (ALL) vs. acute myeloid leukemia (AML) |
(200) |
| leukemia | cloning | miR-21, -150, -155 | miR-92, -222 | various chronic lymphocytic leukemias (CLL) |
(201) |
| leukemia | array | miR-29b, -181b in aggressive CLL with 11q deletion |
three subtypes of CLL | (202) | |
| leukemia | array | miR-16-1,-15a | CLL according to ZAP-70 and IgVH |
(203) | |
| leukemia | array | B-cell CLL | (65) | ||
| various tumors | array cloning |
various sarcomas | (204) | ||
| various tumors | array | solid tumors (lung, breast, stomach, prostate, colon, and pancreatic tumors) |
(122) | ||
| various tumors | bead | comprehensive collection of various cancers and normal tissues |
(64) | ||