Table 3. miRNAs regulated by transcription factors.
Oncogenic or tumor suppressive miRNAs that are directly modulated by transcription factors. The list contains miRNAs whose promoter region was analyzed by a luciferase reporter assay, and more importantly, was shown to bind to the transcription factor by chromatin immunoprecipitation assay
| transcription factor |
target miRNA | note (cancer type, etc) | ref |
|---|---|---|---|
| AR | miR-125b | prostate cancer | (211) |
| MYCN | miR-17-5p, -92, -320 | neuroblastoma | (124) |
| Twist | miR-10b | breast cancer | (146) |
| p53 | miR-34a, miR-34b-34c cluster | cell lines | (60) |
| p53 | miR-34a | cell lines | (137) |
| p53 | miR-34a, miR-34b-34c cluster | cell lines and in vivo | (215) |
| STAT3 | miR-21 | myeloma cell lines | (91) |
| HIF (hypoxia) |
miR-26, -210 | (150) | |
| E2F3 | miR-17-92 cluster | (125) | |
| E2F1, 2, 3 | miR-17-92 cluster | (126) | |
| Myc | miR-17-92 cluster | angiogenesis in colon cancer model | (147) |