Table I. Chemotherapy Schedule.
| Drug | Dose | Schedule |
|---|---|---|
| Induction (Days 0 – 20) | ||
| Vincristine | 1.5 mg/m2 | Days 0, 7, 14 |
| Prednisone | 60 mg/m2/day | Days 0-20 |
| Cyclophosphamide | 1200 mg/m2 | Day 0 |
| Daunomycin | 60 mg/m2 over 48 hours | Day 1 |
| PEG Asparaginase | 2000 IU/m2 | Day 3 |
| Intrathecal cytarabine | Age dependent | Day 0 |
| Intrathecal methotrexate | Age dependent | Day 14 (+ Days 7 and 21 for CNS positive) |
| G-CSF | 5 mcg/kg/day | Day 4 |
| Consolidation (Days 0-20) | ||
| Vincristine | 1.5 mg/m2 | Days 0, 7 |
| Prednisone | Taper from induction | Days 0-6 |
| Etoposide | 200 mg/m2 | Days 0, 1 |
| 6-Thioguanine | 300 mg/m2 | Days 0-3 |
| Cytarabine | 2000 mg/m2 over 3 hours | Days 0, 1 |
| PEG Asparaginase | 1750 IU/m2 | Day 9 |
| Methotrexate | 1 g/m2 over 24 hours | Day 16 |
| Intrathecal methotrexate | Age dependent | Days 14, 21 (+ Day 7 for CNS positive) |
| G-CSF | 5 mcg/kg/day | Day 4 |
| Maintenance (6 courses of 7 week cycles) | ||
| Cyclophosphamide | 1200 mg/m2 | Day 0 |
| 6-Thioguanine | 300 mg/m2 | Days 0-3 |
| Vincristine | 1.5 mg/m2 | Days 14, 21, 28 |
| Prednisone | 180 mg/m2/day | Days 14-20 |
| Doxorubicin | 30 mg/m2 over 1 hours | Day 14 |
| Methotrexate | 1 g/m2 over 24 hours | Day 28 |
| PEG Asparaginase | 1750 IU/m2 | Day 28 |
| Etoposide | 200 mg/m2 | Days 35,36 |
| Cytarabine | 2000 mg/m2 over 3 hours | Days 35,36 |
| G-CSF | 5 mcg/kg/day | As needed |