Table I. Chemotherapy Schedule.
Drug | Dose | Schedule |
---|---|---|
Induction (Days 0 – 20) | ||
Vincristine | 1.5 mg/m2 | Days 0, 7, 14 |
Prednisone | 60 mg/m2/day | Days 0-20 |
Cyclophosphamide | 1200 mg/m2 | Day 0 |
Daunomycin | 60 mg/m2 over 48 hours | Day 1 |
PEG Asparaginase | 2000 IU/m2 | Day 3 |
Intrathecal cytarabine | Age dependent | Day 0 |
Intrathecal methotrexate | Age dependent | Day 14 (+ Days 7 and 21 for CNS positive) |
G-CSF | 5 mcg/kg/day | Day 4 |
Consolidation (Days 0-20) | ||
Vincristine | 1.5 mg/m2 | Days 0, 7 |
Prednisone | Taper from induction | Days 0-6 |
Etoposide | 200 mg/m2 | Days 0, 1 |
6-Thioguanine | 300 mg/m2 | Days 0-3 |
Cytarabine | 2000 mg/m2 over 3 hours | Days 0, 1 |
PEG Asparaginase | 1750 IU/m2 | Day 9 |
Methotrexate | 1 g/m2 over 24 hours | Day 16 |
Intrathecal methotrexate | Age dependent | Days 14, 21 (+ Day 7 for CNS positive) |
G-CSF | 5 mcg/kg/day | Day 4 |
Maintenance (6 courses of 7 week cycles) | ||
Cyclophosphamide | 1200 mg/m2 | Day 0 |
6-Thioguanine | 300 mg/m2 | Days 0-3 |
Vincristine | 1.5 mg/m2 | Days 14, 21, 28 |
Prednisone | 180 mg/m2/day | Days 14-20 |
Doxorubicin | 30 mg/m2 over 1 hours | Day 14 |
Methotrexate | 1 g/m2 over 24 hours | Day 28 |
PEG Asparaginase | 1750 IU/m2 | Day 28 |
Etoposide | 200 mg/m2 | Days 35,36 |
Cytarabine | 2000 mg/m2 over 3 hours | Days 35,36 |
G-CSF | 5 mcg/kg/day | As needed |