Figure 2.
Immunohistochemical staining for HMGA2 protein in pancreatic ductal adenocarcinoma on the tissue microarray (HMGA2 antibody, Gill hematoxylin counterstain). (a) Absent HMGA2 staining in a well-differentiated pancreatic ductal adenocarcinoma. The infiltrating glands do not display nuclear immunoreactivity (magnification × 40, score 0). (b) Moderate HMGA2 staining in a moderately differentiated pancreatic ductal adenocarcinoma. The infiltrating, crowded glands display light background nuclear immunoreactivity and intermittent moderate-to-strong nuclear reactivity (magnification × 64, score 50–150). (c) Strong HMGA2 staining in a poorly differentiated pancreatic ductal adenocarcinoma. The infiltrating cells with enlarged nuclei and minimal gland formation displayed marked nuclear immunoreactivity (magnification × 64, score >150).