Figure 1.

Representation of the ICU-MM. The state variables of the model (G, X, I₁, and I₂) and the body segments (liver and periphery) are denoted as squares and ellipses, respectively. The exogenous input variables (F_I and F_G, administered intravenously to the patient) are illustrated as rhombi. The model parameters (P₁, P₂, P₃, n, α, and γ) are related to the respective variables. A direct physical relation is represented by a solid arrow, whereas a rather mathematical relationship is denoted as a dashed arrow.