Figure 8.

Examples of detection of missed hypoglycemic episodes (encircled in black) in four patients. (A) In patient 21, missed hypoglycemia was detected, however, the classifier overestimated its duration. (B) In patient 9, missed hypoglycemia was correctly detected. Appearance of false negatives was negligible, except during a short period in the final downward trend in glycemia, where consecutive misclassifications appeared. (C) In patient 11, missed hypoglycemia (in this case due to the lag between plasma and interstitial glucose) was correctly detected by the classifier. Misclassifications did not interfere with the main conclusions. (D) In patient 8, the number of misclassifications was higher than in the other patients, however, the missed hypoglycemia between the hours of three and four was detected by the classifier. The same happened with the episode of mild hypoglycemia near hour six.