Figure 4.

Conformal coatings significantly reduce void volume relative to conventional microcapsules and offer a potential approach to protecting islets during intraportal islet transplantation. (A) An islet encapsulated in a conventional alginate microcapsule. (B) Conformal PEG hydrogel coatings fabricated on porcine islets via interfacial polymerization. (Reprinted with permission from Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, Inc.¹³⁰) (C) Islets coated with PEG hydrogel via selective withdrawal, (Adapted with permission from Wyman JL et al.¹²⁸). (D) An alginate hydrogel coating formed on a HEK 293 cell spheroid using an aqueous two phase emulsion. (Reprinted with permission from Wiley-Liss, Inc., a subsidary of John Wiley & Sons, Inc.¹⁶⁸)