Table 3.

Effect of Controller Rules for Insulin Infusion Rate Increases on Blood Glucose Control and Hypoglycemia^a

Controller scheme	Max insulin rate	Max increase in insulin per intervention	Measurement interval (h)	% of measurements			BG median (mg/dl)	LBG-P ratio
				Within 72–126 mg/dl	<72 mg/dl	<47 mg/dl
A	0.5 U/kg/h	0.01 U/kg/h	1	65.9	1.6	0.14	115	0.2
			2	63.5	2.5	0.28	115	0.4
			3	56.9	3.1	0.34	117	0.6
			4	54.9	3.3	0.46	119	0.8
		0.03 U/kg/h	1	81.7	1.7	0.23	110	0.3
			2	76.1	3.4	0.45	108	0.6
			3	69.3	5.8	0.60	110	0.9
			4	64.6	7.1	0.91	110	1.4
		0.05 U/kg/h	1	85.7	1.8	0.23	108	0.3
			2	80.0	3.7	0.68	106	0.9
			3	71.9	6.7	0.94	108	1.3
			4	68.8	7.3	1.37	106	2.0
B		0.1 U/kg/h	1	77.1	1.7	0.14	110	0.2
			2	71.4	3.4	0.28	110	0.4
			3	65.6	5.9	0.94	112	1.4
			4	62.9	6.1	0.91	110	1.5
		0.15 U/kg/h	1	83.9	1.8	0.23	108	0.3
			2	77.9	4.1	0.40	106	0.5
			3	70.6	6.9	1.11	108	1.6
			4	67.0	7.8	1.48	106	2.2
		0.3 U/kg/h	1	89.0	2.5	0.23	106	0.3
			2	79.2	5.8	0.96	106	1.2
			3	72.3	9.1	1.45	106	2.0
			4	68.9	9.4	1.82	104	2.6
		0.5 U/kg/h	1	88.5	3.0	0.39	106	0.5
			2	80.4	6.0	1.13	106	1.4
			3	72.3	8.9	1.96	106	2.7
			4	68.5	10.0	2.73	104	4.0

^aLow-blood-glucose-to-performance ratio compared low BG to performance, which is defined as the ratio of the percentage of measurements <47 mg/dl and the percentage of measurements within the 72–126 mg/dl range.