Table 3.
Outcomes of Sample Reduction Stepsa
| Steps (# samples) | 1 (23) | 2 (6) | 3 (6) | 4 (4) | 5 (6) | ||
|---|---|---|---|---|---|---|---|
| Reference | Percentile change [%] | ||||||
| NGT | |||||||
| Smax | Mean (geom) | 2578.8 | Mean | –5.52 | –7.58 | –5.52 | –1.80 |
| (pmol/min) | SD (multipl) | 1.8 | SD | 1.61 | 5.68 | 1.59 | 5.27 |
| correlation | 1.00 | 0.99 | 1.00 | 1.00 | |||
| tpeak | Median | 3 | Median | 0 | 0 | 0 | 0 |
| (min) | SD | 0.0 | SD | 0.0 | 0.0 | 0.0 | 0 |
| AUC10 | Mean (geom) | 10301.8 | Mean | –5.21 | 2.23 | 10.10 | –0.71 |
| (pmol) | SD (multipl) | 1.8 | SD | 1.56 | 3.10 | 9.28 | 2.243 |
| correlation | 1.00 | 1.00 | 0.99 | 1.00 | |||
| AUC20 | Mean (geom) | 15110.8 | Mean | –3.24 | –0.54 | 8.40 | –0.62 |
| (pmol) | SD (multipl) | 1.7 | SD | 9.97 | 9.84 | 9.34 | 9.56 |
| correlation | 0.97 | 0.97 | 0.97 | 0.97 | |||
| AUCtotal | Mean (geom) | 42648.9 | Mean | 4.95 | 19.44 | 9.30 | 5.70 |
| (pmol) | SD (multipl) | 1.4 | SD | 4.42 | 6.53 | 3.98 | 3.76 |
| correlation | 0.99 | 0.99 | 1.00 | 1.00 | |||
| T2DM | |||||||
| Smax | Mean (geom) | 826.3 | Mean | –15.64 | –2.36 | –15.30 | –0.61 |
| (pmol/min) | SD (multipl) | 2.5 | SD | 14.32 | 12.07 | 13.91 | 21.47 |
| correlation | 1.00 | 1.00 | 1.00 | 0.96 | |||
| tpeak | Median | 3 | Median | 0 | 0 | 0 | 0 |
| (min) | SD | 0.8 | SD | 0.8 | 0.8 | 3.0 | 1.11 |
| AUC10 | Mean (geom) | 4600.7 | Mean | –6.40 | –0.73 | 5.42 | –2.39 |
| (pmol) | SD (multipl) | 2.5 | SD | 5.83 | 9.27 | 27.14 | 10.88 |
| correlation | 1.00 | 1.00 | 0.99 | 1.00 | |||
| AUC20 | Mean (geom) | 9439.8 | Mean | –4.23 | –4.47 | –6.76 | –2.23 |
| (pmol) | SD (multipl) | 2.4 | SD | 9.38 | 12.74 | 20.27 | 8.66 |
| correlation | 0.99 | 0.98 | 0.95 | 0.99 | |||
| AUCtotal | Mean (geom) | 82523.7 | Mean | 0.43 | –0.52 | –1.32 | 0.63 |
| (pmol) | SD (multipl) | 2.2 | SD | 5.18 | 4.36 | 6.21 | 5.39 |
| correlation | 1.00 | 1.00 | 1.00 | 1.00 | |||
a
Relative percentile changes of steps 2–5 are shown compared to reference step 1 (tpeak is given as absolute difference in minutes). Results from step 1 have a log-normal distribution and are described by the log-normal geometric mean (geom) and the multiplicative standard deviation (multipl). Relative changes in steps 2–5 are distributed normally and are described by the mean and standard deviation (SD). Correlations shown are steps 2–5 compared to step 1 (P < 0.001).