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. Author manuscript; available in PMC: 2010 Sep 16.
Published in final edited form as: J Am Chem Soc. 2009 Sep 16;131(36):13107–13116. doi: 10.1021/ja904271k

Figure 1.

Figure 1

Contacts of a red guest residue at a mutant site i within a typical α-helix (a) and within an idealized α-helix in which local context effects are minimal (b). In (a), the red guest atoms contact the cyan neighboring backbone as well as side chain atoms of residues at (i ± 3) and (i ± 4) separations (green, magenta, orange, and blue circles). Both helical propensities and context effects are required to characterize the energetics of these interactions. For case (b), the contacts between side chains are minimal, and only the cyan contacts perturb helicity significantly. Their sequence-independent energetics are defined by the helical propensities.