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. 2009 Jul 1;81(5):850–855. doi: 10.1095/biolreprod.109.078667

FIG. 5.

FIG. 5.

Effect of 25-hydroxycholesterol (22-OH cholesterol) (3–30 μM) on proliferation of ovarian theca-interstitial cells in the absence and presence of simvastatin (10 μM). The cells were cultured as described for Figure 1. A) Effects on DNA synthesis. B) Effects on the number of viable cells. Each bar represents the mean ± SEM (N = 8). *Denotes means significantly different from control in the absence of 25-hydroxycholesterol (P < 0.05). †Denotes means significantly different from simvastatin alone (P < 0.05 [applies only to comparison among cultures containing simvastatin]).