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. 2009 Jul 1;81(5):850–855. doi: 10.1095/biolreprod.109.078667

FIG. 7.

FIG. 7.

Outline of the mevalonate pathway. Conversion of acetoacetyl-coenzyme A to HMG-CoA to mevalonic acid is regulated by HMG-CoA reductase, the rate-limiting step of cholesterol synthesis. Statins competitively inhibit HMG-CoA reductase. Products of mevalonic acid include FPP (farnesyl PP) and GGPP (geranylgeranyl PP). Farnesyl pyrophosphate is required for farnesylation; this step is inhibited by FTI. Geranylgeranyl pyrophosphate is required for geranylgeranylation; this step is inhibited by GGTI.