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Papilloma outgrowth in rabbits challenged with wild type CRPV DNA and an E2ATGko mutant genome inserted as a tandem repeat plasmid that additionally contains a wild type E2 gene in sense orientation (see Materials and Methods and Figure 1). Significantly smaller tumors were found at sites challenged with the mutant when compared with those induced by wild type CRPV (P<0.05, unpaired student T test).
