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CYR61 stimulates neovascularization in rat cornea. Hydron pellets containing test (or control) samples were formulated and implanted into corneas of rats as described in Materials and Methods (also see Table 1). New blood vessels that formed were visualized by perfusion with colloidal carbon 7 days after implantation. Hydron pellets contained (A) CYR61; (B) bFGF; (C) CYR61 storage buffer; or (D) CYR61 protein preincubated with anti-Cyr61 antibodies.
