Figure 3. Dose-dependent effects of niflumic acid on murine gastric antrum slow waves.

A shows dose-dependent effects on slow wave frequency. Concentrations of 1 μm or greater caused a dose-dependent reduction in slow wave frequency (IC₅₀= 5.42 ± 0.3). Slow waves were abolished at 30 μm or greater. B shows individual slow waves at a faster sweep speed at each concentration of niflumic acid. C and D show summaries (n= 7) of the dose-dependent effects of niflumic on antral slow wave frequency and duration. Filled circles represent recording under control conditions.