Figure 4. Dose-dependent effects of niflumic acid on monkey gastric antrum slow waves.

A shows cumulative doses (1–100 μm) on antral slow waves. Concentrations of 1 μm and above caused a dose-dependent decrease in slow wave frequency (IC₅₀= 3.59 ± 1.4 μm). Slow wave activity was abolished at 100 μm. B shows slow waves at an expanded time scale at each concentration of niflumic acid. C and D show summaries (n= 6) of the dose-dependent effects of niflumic on antral slow wave frequency and duration. Filled circles represent recording under control conditions.