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Hypothalamic POMC promoter methylation, presented as a function of neonatal blood glucose levels (A), and hypothalamic POMC expression calculated per corresponding level of leptin (B), and insulin (C), presented as a function of the percentage of CpG residues that are methylated upstream of the SP1 binding sequence of the POMC promoter. Correlation coefficients and significances derived from Spearman rank correlation test.
