Figure 2.
RELMβ KO mice remain comparatively lean on a high fat diet compared to wild-type littermate controls. A) Body weight of female RELMβ wild-type (WT) and Knockout (KO) mice at 13 weeks of age on a standard chow diet or after 21 weeks on a high fat diet, Mean±SEM, N=4-5 mice per group; *p<0.05; B) MRI body composition analysis after 8 weeks on the high fat diet, Mean±SEM, N=4-5 mice per genotype, *p=0.004; C) Daily food intake in RELMβ KO and wild-type mice fed a high fat diet for 4 weeks, Mean±SEM, N=4-5 mice per genotype; D) Percent dietary fat absorbed by RELMβ KO and wild-type mice fed a high fat diet for 5 weeks, Mean±SEM, N=4-5 mice per genotype; E) Rectal temperatures of RELMβ KO and wild-type mice fed a high fat diet for 8 weeks, Mean±SEM, N=4-5 mice per genotype; F) Oxygen consumption (VO2) measured via indirect calorimetry over 4 hours (light cycle) in RELMβ KO and wild-type mice after 21 weeks on a high fat diet, Mean±SEM, N=4 mice per group, *p<0.0001.