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. Author manuscript; available in PMC: 2009 Oct 29.
Published in final edited form as: J Neurosci Res. 2009 Jul;87(9):2078–2086. doi: 10.1002/jnr.22023

Fig. 4.

Fig. 4

E2 was protective against hypoxia/ischemia-induced white matter injury. A: Of 14 cases treated with vehicle, injury was significantly higher on the ipsilateral than on the contralateral side (mean 3.8 vs. 1.2 ± SEM, # # #P < 0.001). Of the 15 cases treated with estrogen, injury was also significantly higher on the ipsilateral than on the contralateral side (mean 1.7 vs. 0.5 ± SEM, # # #P < 0.001). Thus, injury was always higher on the ipsilateral side than the contralateral side regardless of treatment. Injury on the ipsilateral side was significantly lower in the group treated with estrogen (***P < 0.001). B: In the cases treated with estrogen, there was no significant difference in injury by dose: 300 versus 600 µg/kg (ipsilateral: mean 1.6 vs. 1.7 ± SEM, P = 0.90; contralateral: mean 0.6 vs. 0.3 ± SEM, P = 0.34).