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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Bioessays. 2009 Feb;31(2):139–152. doi: 10.1002/bies.200800123

Figure 1. Organization of the zebrafish digestive tract and pancreatic islet.

Figure 1

A) Fate mapping from 4 hpf shows that anterior endodermal organs derive from precursors close to the dorsal organizer whereas posterior organs derive from more ventral locations(4). The islet is organized similarly to the mammalian islet. DO: Dorsal Organizer. B) Fate mapping shows that pancreatic precursors (red box, 5 hpf) derive from the blastoderm margin, in bilateral domains. By the end of gastrulation (10 hpf), the precursors have converged towards the trunk region. By the end of day 1 of development, differentiated endocrine cells cluster to form the islet in the anterior trunk region.