Table 3.

Pancreas-related transgenic lines.

line	transgene	expression	reference
ins:GFP	insulin driving Green Fluorescent Protein (GFP)	β-cells	(111)
pdx1:GFP	pancreatic duodenal homeobox-1 driving GFP	pancreas progenitors	(111)
XlEef1a1:GFP (gutGFP)	Xenopus laevis elongation factor-1a driving GFP*	throughout endoderm from 22 hpf	(11,112)
ptf1a:eGFP	pancreas specific transcription factor, 1a driving enhanced GFP	exocrine pancreas	(113)
sox17:GFP	SRY-box containing gene 17 driving GFP	endoderm percursors	(114)
sox17:dsRed	SRY-box containing gene 17 driving dsRed	endoderm percursors	(45)
elaA:EGFP	elastaseA driving GFP	exocrine pancreas	(67)
ins:eGFP	insulin driving enhanced GFP	β-cells	(9)
ins:mCherry	insulin driving mCherry	β-cells	(9)
ins:nfsB-mCherry	insulin driving nfsB-mCherry fusion protein†	β-cells	(9)
glu:GFP	glucagon driving GFP	α-cells	(9)
ins:gal4	insulin driving Gal4	β-cells	(9)
ins:kaede	insulin driving photoconvertable Kaede	β-cells	(9)
nkx2.2a:GFP	NK2 transcription factor related 2a driving GFP	endocrine pancreas	(55,81)
nkx2.2a:mEGFP	as above, with enhanced GFP localized to the membrane	endocrine pancreas	(112)
ins:CFP-NTR	insulin driving Cyan Fluorescent Protein (CFP) fused to Nitroreductase	β-cells	(68)
hsp70l:nog3	noggin3 is inducible via heat shock cognate 70-kd protein, like	inducible, ubiquitous‡	(115)

For specific alleles and further information, see the Zebrafish Information Network (ZFIN).

^*The transgene integrated into the 3’UTR of Foxa3.

^†nsfB (nitrofurazone sensitivity) is an E. coli gene with nitroreductase (NTR) activity. Addition of the drug metronidazole induces NTR-mediated ablation.

^‡Noggin3 inhibits BMP signaling, resulting in failure of gut looping and pancreas duplication.