Table 1.

Factors positively and negatively affecting adherence

Positive	Negative
Perceived benefit of treatment	Poor insight
Proper psycho-education	Cognitive dysfunction; psychotic symptoms
Optimal psychopharmacology (once a day dosing, few adverse effects, good efficacy)	Side effects (weight gain, sedation, orthostasis, akathesia)
Good therapeutic alliance	Poor efficacy
Fear of hospitalization	Substance abuse
Social support	Environmental factors (lack of trust in physicians, high cost of medication, limited social support)