Table 1.
Chr. | SNP | Position (B36) | Minor allele | MAF, affected | MAF, control | P value | Bonferonni P | OR | 95% CI | Relevant gene |
---|---|---|---|---|---|---|---|---|---|---|
1 | rs11209026 | 67478546 | A | 0.024 | 0.061 | 7.47 × 10−11 | 3.84 × 10−5 | 0.385 | 0.29–0.52 | IL23R |
16 | rs5743289 | 49314275 | T | 0.232 | 0.172 | 3.77 × 10−10 | 0.00019 | 1.455 | 1.29–1.64 | NOD2 |
1 | rs11465804 | 67475114 | G | 0.030 | 0.065 | 1.46 × 10−9 | 0.00075 | 0.442 | 0.34–0.58 | IL23R |
6 | rs477515 | 32677669 | T | 0.248 | 0.313 | 1.02 × 10−8 | 0.0052 | 0.724 | 0.65–0.81 | HLA-DRB1 |
6 | rs2516049 | 32678378 | G | 0.248 | 0.313 | 1.06 × 10−8 | 0.0054 | 0.724 | 0.65–0.81 | HLA-DRB1 |
6 | rs9271568 | 32698441 | A | 0.238 | 0.301 | 2.95 × 10−8 | 0.015 | 0.724 | 0.65–0.81 | HLA-DQA1 |
9 | rs6478109 | 116608587 | A | 0.251 | 0.314 | 3.20 × 10−8 | 0.016 | 0.733 | 0.66–0.82 | TNFSF15 |
21 | rs2836878 | 39387404 | A | 0.214 | 0.273 | 6.01 × 10−8 | 0.031 | 0.725 | 0.65–0.81 | PSMG1 |
20 | rs2315008 | 61814400 | T | 0.250 | 0.311 | 6.30 × 10−8 | 0.032 | 0.737 | 0.66–0.82 | TNFRSF6B |
20 | rs4809330 | 61820030 | A | 0.249 | 0.310 | 6.95 × 10−8 | 0.036 | 0.738 | 0.66–0.82 | TNFRSF6B |
9 | rs6478108 | 116598524 | C | 0.262 | 0.324 | 8.36 × 10−8 | 0.043 | 0.743 | 0.67–0.83 | TNFSF15 |
16 | rs2076756 | 49314382 | G | 0.317 | 0.258 | 9.65 × 10−8 | 0.050 | 1.332 | 1.20–1.48 | NOD2 |
Newly identified signals are indicated in boldface. Minor allele frequencies (MAF), P values and odds ratios (OR) are shown. The ORs shown are for the minor alleles (as observed in the controls). Combined P values are also shown, together with the most relevant gene in which the markers reside or which they are nearest to. P values are two sided and uncorrected in each instance.