Table 1.
Characteristics of the 63 patients who received ddI/d4T (Group 1) versus ZDV/3TC (Group 2) as first-line therapy
| Group 1 (n = 26) |
Group 2 (n = 37) |
|
|---|---|---|
|
Age (years) Median Interquartile range |
35 [24-57] |
34 [21-48] |
| Female sex (%) | 61.5 | 60.7 |
|
Baseline nadir CD4 cell count Median Interquartile range |
96 [2-276] | 61 [1-317] |
|
CD4 cell count at failure visit Median Interquartile range |
334 [41-937] |
233 [9-1313] |
|
Log10 HIV-1 RNA at failure visit Median Interquartile range |
4.2 [2.9-5.33] |
4.7 [3.5-5.9] |
|
Total days on antiretroviral therapy at the time of genotype Median Interquartile range |
998 [228-2507] |
486 [59-1346] |
|
Total time (days) to non-detectability of viral load (<400 copies/ml) at the time of genotype Median Interquartile range |
158 [28-1693] |
96 [10-1188] |
| Average number of ARV regimens received by the time of genotype | 3* | 2.5† |
*Group 1 - ARV regimens received by the time of genotyping. ddI/d4T/NVP, ZDV/3TC/EFV, ddI/d4T/NFV; ddI/d4T/NVP, ZDV/3TC/NVP, d4T/3TC/NVP, ABC/ddI/NFV; ddI, ddI/d4T/NVP; ddI/ZDV, ddI/d4T/EFV, ZDV/3TC/NFV; ddI/ZDV/3TC, ZDV/3TC/NVP, ABC/ddI/NFV; ddI/d4T/EFV, ZDV/3TC/EFV, ddI/d4T/NFV; ddI/d4T/NVP, ZDV/3TC/NFV (n = 2); ddI/d4T, ZDV/3TC/NVP, ddI/TDF/LPVr; ddI/d4T/EFV, ZDV/3TC/EFV (n = 3); ddI/ZDV, ZDV/3TC/NVP, ddI/d4T/NFV; ddI/d4T/NVP, ZDV/3TC/NFV, LPVr/SQV; ddI/ZDV/NVP, 3TC/d4T/NFV; ddI/d4T, ZDV/3TC/EFV, ddI/d4T/SQV/RTV; ddI/d4T/NVP, ZDV/3TC/NFV, ZDV/TDF/LPVr; ddI/ZDV/NVP, 3TC/d4T/IDV/RTV; ddI/d4T/EFV, ddI/d4T/NFV; ddI/d4T, ddI/d4T/NVP, ZDV/3TC/EFV; ddI/d4T/NVP, ZDV/3TC/NVP; ddI/d4T, 3TC/ddI, ZDV/3TC/NVP, ZDV/3TC/EFV; ddI/d4T, ZDV/3TC/SQV/RTV, ZDV/3TC/NVP; ddI/d4T/EFV, ZDV/3TC/EFV, ABC/ddI/NFV, ddI/d4T/EFV/LPV; ddI/d4T/EFV, ABC/ddI/NFV, d4T/3TC/EFV; ddI/ZDV/NVP, d4T/3TC/IDV, ddI/d4T/NFV.
†Group 2 - ARV regimens received by the time of genotyping. ZDV/3TC/NVP; ZDV/3TC/NVP, ddI/d4T/NVP, ZDV/3TC/NVP, 3TC/ddI/NFV, 3TC/ABC/ddI/LPV; ZDV/3TC/NVP, ddI/d4T/NFV (n = 13); ZDV/SQV/RTV, ddI/d4T, ddI/d4T/NFV, 3TC/ABC/LPV; ZDV/3TC/EFV, ddI/TDF/LPV; ZDV/3TC/IDV, ZDV/3TC/NVP, ddI/d4T/NVP; ABC/ddI/NVP; 3TC/d4T/NVP, ZDV/ddI/NFV; ZDV/3TC/NVP, ddI/d4T/NFV, ZDV/3TC/LPV; ZDV/3TC/EFV, ddI/d4T/NFV (n = 5); ZDV/3TC/NVP, ddI/d4T/NFV, ABC/SQV/RTV; ZDV/3TC/NVP, ddI/d4T/NFV, ABC/ddI/NFV; ZDV/3TC, SQV/RTV, ddI/d4T/SQV/RTV, ABC/d4T/ddI/LPV, 3TC/ddI/EFV; 3TC/d4T/EFV, ZDV/3TC/NFV; 3TC/d4T/EFV (n = 2); ZDV/3TC/EFV, 3TC/d4T/NVP; ZDV/3TC/EFV, ABC/ddI/NFV; ZDV/3TC/EFV (n = 2); ZDV/3TC, IDV/NVP, 3TC/ABC/d4T, d4T/EFV/IDV/RTV, 3TC/ABC/d4T, 3TC/ABC/d4T/LPV, 3TC/ABC/AZT/LPV.