Table 3.

Significant correlations of pairs of mutations within PR

Mutations	Correlated mutations		Pearson coeff.		Jaccard coeff.		P value (freq cell)
	Group 1	Group 2	Group 1	Group 2	Group 1	Group 2	Group 1	Group 2
L10F/I	K20R/T/I/M	M46I	36.9	36.7	36.4	33.3	0.13 (15.4)	0.07 (13.5)
	D30N	A71V	42.8	37.1	37.5	28.5	0.06 (11.5)	0.04 (10.8)
	Q61E/D		42.8		37.5		0.06 (11.5)
	T74S	T74S	65.9	44.4	57.1	43.7	0.005 (15.4)	0.02 (0.02)
	N88D	N88D	65.9	40.36	50	23	0.008 (11.5)	0.04 (8.1)
	N88S		52		33		0.05 (7.7)
K20R/T/I/M	E35D/N	E35D/N	40.4	50.1	46.7	65.4	0.10 (26.9)	0.006 (45.9)
	M46I	K45Q	39.7	38.4	0	28.5	0.11 (7.7)	0.03 (16.2)
	T74S		46.5				0.03 (15.4)
	V77I		39.7				0.11 (7.7)
	N88S		39.7				0.11 (7.7)
D30N	K45Q	K45Q	41	60.5	20	50	0.19 (3.85)	0.002 (13.5)
	N88D	N88D	74	52.4	60	33.3	0.004 (11.5)	0.01 (8.1)
	L89I		50.5		42.8		0.03 (11.5)
E35D/N	T74S		48.8		38.5		0.04 (19.2)
M46I		A71V		41.5		33.3	0.04 (8.1)
		V77I		41.5		33.3	0.04 (8.1)
D60E		Q61E/D		48.6		50	0.005 (24.32)
Q61E/D	N88S		59		40		0.03 (7.7)