Figure 4.

CWO regulates the loops. (a–f) mRNA concentrations of cwo, tim, per, vri, pdp1, and CLK-CYC in response to selective activation of the repressive actions of CWO in DD conditions. Blue and black lines represent the wt and mutant models, respectively. The yellow line denotes the selective activation of the CWO autorepressive loop (cwo, CWO) and the Pdp1 positive loop (pd). Red and green lines denote the activation of three CWO-repressive actions, the CWO autorepressive loop plus the Pdp1 positive loop plus one of either the vri (red) or the per/tim (green) negative loops, respectively.