Figure 5.

Integration of opposite transcriptional signals. (a) Bar plot of the absolute values of the positive (Δx_C/C(t_g)λ_C/C,g; red) and negative (x_CWO(t_g)|λ_CWO,g|; blue) transcriptional signals at the peak of each direct-target gene in the wt model in LD. (b) The cumulative effects of the actions of the CWO protein on the three loops cause an increase in peak levels of CLK-CYC (Δx_C/C > 0), which leads to higher peaks of vri, Pdp1, per, and tim, because the values of the positive signals are larger than those of the negative signals. The transcription of cwo is repressed because the negative signal is dominant. The term x_CWO(t_g) refers to the concentration of CWO protein at the time of the peak of a direct-target gene.