Table 1.
Parameter values for Fig. 1
| Param. | Value | Param. | Value | Param. | Value | |
|---|---|---|---|---|---|---|
| r∗ | 0.2 μM | sa∗ | 0.01 μM | Cm | 5 300 fF | |
| fcyt; fer | 0.01 | τa | 300,000 ms | 300 pS | ||
| Vcyt/Ver | 5 | pleak | 0.0005 ms−1 | νn | −16 mV | |
| KD | 0.3 μM | α | 4.5 × 10−6 fA−1μM ms−1 | sn | 5 mV | |
| kPMCA | 0.2 ms−1 | kSERCA | 0.4 ms−1 | νm | −20 mV | |
| VK | −75 mV | τn | 16 ms | sm | 12 mV | |
| VCa | 25 mV | gK | 3000 pS | p | 5 | |
|
|
30,000 pS | gCa | 1200 pS |
The main change is an increase in so that it can be interpreted as the total KATP conductance in the cell, rather than the residual conductance at stimulatory glucose; this also entails a change in the range of values of r. The decrease in sa was chosen to limit the shift in the glucose dose response curve (compare Figs. 2 and 4). Figure legends indicate variations from the table.
Values modified from Bertram and Sherman (3).