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. Author manuscript; available in PMC: 2010 Sep 15.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Jul 19;19(18):5482–5485. doi: 10.1016/j.bmcl.2009.07.080

Scheme 2.

Scheme 2

(a) 2-methyl-3-butyn-2-ol, Pd(PPh3)2Cl2, Et3N, CuI, DMF, N2, rt, 7 h, 78%; (b) NaOH, toluene, reflux, 16 h, 69%.