Fig. 3.

VP GABA efflux (% Baseline) in SD (a) and LE (b) rats after vehicle or 0.5 mg/kg APO s.c. (at Time = 0 min). GABA efflux after APO in SD rats declined rapidly to almost 60% baseline levels, where it stayed for 120 min. * Significant reduction in VP GABA efflux compared to vehicle dose (all p values < 0.05). GABA efflux after APO in LE rats remained relatively stable. VP glutamate efflux (% Baseline) in SD (c) and LE (d) rats after vehicle or 0.5 mg/kg APO s.c. (at Time = 0 min). No significant effects of drug or strain on VP glutamate efflux were detected, though an injection artifact was noted after vehicle injection in two LE rats (d)