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. 2009 Aug 25;37(19):6635–6643. doi: 10.1093/nar/gkp615

Figure 1.

Figure 1.

The SICs for monitoring the [M – H]– ions of p(mdCg)pdG [m/z 683, (a)] and pTgpdG [m/z 684, (c)], as well as for monitoring the m/z 683 →524, 567 transitions of p(mdCg)pdG (b) and for monitoring the m/z 684 →541 transition of pTgpdG (d). The sample was the nuclease P1 digestion mixture of 27-mer mC-containing duplex DNA after it was treated with Fenton reagent and deaminated at 37°C for 24 h (details are described in ‘Materials and Methods’ section). Shown also are the SICs for the m/z 684 →541 transition for the analyses of the nuclease P1 digestion mixtures of a ODN, d(ATGGCTgGGCTAT), which contains the (5R,6S) diastereomer of Tg (e) and the nuclease P1 digestion mixture of d(ATGC) that has been treated with OsO4 (f). The MS/MS of the deprotonated ions of p(mdCg)pdG and pTgpdG are shown in Figures S2–S4.