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. 2009 Aug 27;37(19):6400–6413. doi: 10.1093/nar/gkp705

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — DNA double-strand breaks caused by MMC are dependent on replication elongation. (A) irs1SF, UV4DR7 and ERCC1.17 cells were treated with 10 μM MMC^+/− 3 μM Aphidocolin for 4 h prior to analysis by pulsed-field gel electrophoresis; 2 mM hydroxyurea (HU) treated cells (24 h) were used as positive control. (B) Fragment analysis of released DNA. (C) Quantification of MMC-induced DSBs in presence or absence of Aphidocolin.