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. 2009 Aug 27;37(19):6400–6413. doi: 10.1093/nar/gkp705

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Mitomycin C inhibits replication elongation. (A) Replication elongation can be measured as the time it takes to prevent release of ³H-thymidine-labelled DNA onto the ssDNA fraction (37). (B) Time-course of replication fork progression in AA8 cells after a 15-min MMC treatment (100 µM). (C) Dose-dependent replication elongation inhibition in AA8 hamster cells 2 h following MMC treatments. The means and standard deviation (bars) of three independent experiments are shown. Statistical significance determined in t-test is indicated with one star (P < 0.05), two stars (P < 0.01) and three stars (P < 0.001).