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. 2009 Sep 4;37(19):6439–6453. doi: 10.1093/nar/gkp720

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Long patch gap-filling DNA synthesis associated with enhanced 3′–5′ exonuclease activity of PfuAPE. The proposed model of the BER process in P. furiosus is shown. The UDG–PCNA–APE complex searches for the uracil site on the DNA strand and works to remove the uracil and cleave the DNA strand, respectively (steps 1 and 2). Then, the produced nick is expanded by the exonuclease of APE with the help of PCNA, to make a gap suitable for the appropriate binding of DNA polymerase (step 3) and then DNA polymerase fills in the gap to repair the double strand DNA (step 4).