Table 3.
Genes up-regulated in CD4+ T cells from cord blood samples 1 and 2 (CB 1 and CB 2, respectively)
| Fold change |
||||||
|---|---|---|---|---|---|---|
| Affi ID | Gene abbreviation | CB 1 | CB 2 | PB 1 | PB 2 | Gene name |
| Apoptosis | ||||||
| 1555372_at | BimL | 1·39 | 1·52 | 0·61 | 0·42 | BCL2-like 11 (apoptosis facilitator) |
| 237837_at | BCL2 | 1·27 | 1·32 | 0·49 | 0·73 | B-cell CLL/lymphoma 2 |
| 205681_at | BCL2A1 | 1·91 | 1·53 | 0·39 | 0·47 | BCL2-related protein A1 |
| 1558143_a_at | BCL2L11 | 1·68 | 1·74 | 0·32 | 0·32 | BGL2-like 11 (apoptosis facilitator) |
| 228311_at | BCL6B | 1·36 | 3·39 | 0·64 | 0·26 | B-cell CLL/lymphoma 6, member B (zinc finger protein) |
| 215037_s_at | BCLX | 2·56 | 1·27 | 0·73 | 0·56 | BCL2-like 1 |
| 224414_s_at | CARD6 | 2·65 | 1·34 | 0·56 | 0·66 | Caspase recruitment domain family, member 6 |
| 201631_s_at | IER3 | 1·62 | 2·95 | 0·38 | 0·31 | Immediate early response 3 |
| 218000_s_at | PHLDA1 | 2·34 | 1·21 | 0·53 | 0·79 | Pleckstrin homology-like domain, family A, member 1 |
| 209803_s_at | PHLDA2 | 2·87 | 1·32 | 0·31 | 0·68 | Pleckstrin homology-like domain, family A. member 2 |
| 203063_at | PPMIF | 1·26 | 1·53 | 0·74 | 0·64 | Protein phosphatase IF (PP2C domain containing) |
| 205214_at | STK17B | 1·78 | 1·26 | 0·74 | 0·71 | Serine/threonine kinase 17b (apoptosis-inducing) |
| 217853_at | TENS1 | 1·63 | 6·00 | 0·04 | 0·37 | Tensin 1 |
| B- and T-cell development | ||||||
| 211861_x_at | CD28 | 1·35 | 1·41 | 0·49 | 0·65 | CD28 antigen(Tp44) |
| 207892_at | CD40LG | 3·67 | 1·32 | 0·45 | 0·68 | C040 ligand (TNF superfamily, member 5, hyper-IgM syndrome) |
| 206914_at | CRTAM | 2·76 | 1·60 | 0·40 | 0·36 | Class I MHC-restricted T-cell-associated molecule |
| 210557_x_at | CSF1 | 3·79 | 1·22 | 0·78 | 0·70 | Colony-stimulating factor 1 (macrophage) |
| 210229_s_at | CSF2 | 1·28 | 2·67 | 0·69 | 0·72 | Colony-stimulating factor 2 (granulocyte–macrophage) |
| 205159_at | CSF2RB | 2·33 | 1·60 | 0·18 | 0·40 | Colony-stimulating factor 2 receptor |
| 231794_at | CTLA4 | 1·39 | 1·26 | 0·74 | 0·44 | Cytotoxic T-lymphocyte-associated protein 4 |
| 204232_at | FCER1G | 1·63 | 2·14 | 0·28 | 0·37 | Fc fragment of IgE, high affinity 1, receptor for; gamma polypeptide |
| 210439_at | ICOS | 1·38 | 1·34 | 0·57 | 0·66 | Inducible T-cell costimulator |
| 210354_at | IFNG | 1·48 | 1·92 | 0·46 | 0·52 | Human mRNA for HuIFN -gamma interferon |
| 230536_at | PBX4 | 1·48 | 1·26 | 0·50 | 0·74 | Pre-B-cell leukaemia transcription factor 4 |
| 215540_at | TCRA | 1·25 | 1·87 | 0·67 | 0·75 | T-cell antigen receptor alpha |
| 234440_al | TCRD | 7·51 | 1·48 | 0·50 | 0·52 | Human T-cell receptor delta-chain |
| Cell growth and maintenance | ||||||
| 213497_at | ABTB2 | 2·06 | 1·34 | 0·66 | 0·63 | Ankyrin repeat and BTB (POZ) domain containing 2 |
| 201236_s_at | BTG2 | 1·60 | 1·23 | 0·60 | 0·77 | BTG family, member 2 |
| 235287_at | CDK6 | 1·50 | 1·32 | 0·44 | 0·68 | Cyclin-dependent kinase 6 |
| 209644_x_at | CDKN2A | 2·90 | 1·21 | 0·67 | 0·79 | Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) |
| 236313_at | CDKN2B | 3·24 | 1·28 | 0·58 | 0·72 | Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
| 241984_at | CHES1 | 1·38 | 1·34 | 0·66 | 0·63 | Checkpoint suppressor 1 |
| 202552_s_at | CRIM1 | 1·94 | 1·39 | 0·32 | 0·61 | Cysteine-rich transmembrane BMP regulator 1 (chordin-like) |
| 204844_at | ENPEP | 1·64 | 1·75 | 0·09 | 0·36 | Glutamyl aminopeptidase (aminopeptidase A) |
| 205418_at | FES | 1·39 | 1·80 | 0·61 | 0·25 | Feline sarcoma oncogene |
| 228572_at | GRB2 | 4·69 | 1·21 | 0·79 | 0·78 | Growth factor receptor-bound protein 2 |
| 207688_s_at | INHBC | 1·46 | 1·25 | 0·51 | 0·75 | Inhibin, beta C |
| 209744_x_at | ITCH | 1·30 | 1·47 | 0·63 | 0·70 | Itchy homolog E3 ubiquitin protein ligase (mouse) |
| 201548_s_at | JARID1B | 1·27 | 1·92 | 0·73 | 0·46 | Jumonji, AT-rich interactive domain IB (RBP2-like) |
| 203297_s_at | JARID2 | 1·42 | 1·28 | 0·54 | 0·72 | Jumonji, AT-rich interactive domain 2 |
| 41387_r_at | JMJD3 | 1·82 | 1·24 | 0·76 | 0·65 | Jumonji domain containing 3 |
| 205569_at | LAMP3 | 2·32 | 1·24 | 0·76 | 0·50 | Lysosomal-associated membrane protein 3 |
| 214039_s_at | LAPTM4B | 1·41 | 1·49 | 0·49 | 0·59 | Lysosomal-associated protein transmembrane 4 beta |
| 205857_x_at | MSH3 | 1·79 | 1·28 | 0·58 | 0·72 | MutS homolog 3 (E. coli) |
| 209550_at | NDN | 3·42 | 1·38 | 0·17 | 0·62 | Necdin homolog (mouse) |
| 207943_x_at | PLAGL1 | 1·37 | 1·43 | 0·57 | 0·63 | Pleiomorphic adenoma gene-like 1 |
| 204748_at | PTGS2 | 1·65 | 1·78 | 0·14 | 0·35 | Prostaglandin-endoperoxide synthase 2 |
| 201482_at | QSCN6 | 1·32 | 1·23 | 0·38 | 0·77 | Quiescin Q6 |
| 203743_s_at | TDG | 1·47 | 1·23 | 0·54 | 0·77 | Thymine-DNA glycosylase |
| 204227_s_at | TK2 | 2·12 | 1·26 | 0·56 | 0·74 | Thymidine kinase 2, mitochondrial |
| Cytokines and chemokines | ||||||
| 207533_at | CCL1 | 1·67 | 1·48 | 0·52 | 0·49 | Chemokine (C-C motif) ligand 1 |
| 205099_s_at | CCR1 | 4·70 | 1·21 | 0·61 | 0·79 | Chemokine (C-C motif) receptor 1 |
| 207681_at | CXCR3 | 1·51 | 1·33 | 0·41 | 0·67 | Chemokine (C-X-C motif) receptor 3 |
| 211469_s_at | CXCR6 | 1·58 | 1·95 | 0·32 | 0·42 | Chemokine (C-X-C motif) receptor 6 |
| 206613_at | IL-18R1 | 2·32 | 1·38 | 0·61 | 0·62 | Interleukin-18 receptor 1 |
| 207072_at | IL-18RAP | 2·16 | 1·44 | 0·46 | 0·56 | Interleukin-18 receptor accessory protein |
| 212657_s_at | IL-1RN | 1·44 | 3·12 | 0·56 | 0·37 | Interleukin 1 receptor |
| 206341_at | IL-2RA | 1·52 | 1·27 | 0·73 | 0·66 | Interleukin-2 receptor alpha |
| 202859_x_at | IL-8 | 1·31 | 3·75 | 0·38 | 0·69 | Interleukin-8 |
| 202643_s_at | TNFAIP3 | 1·61 | 1·25 | 0·67 | 0·75 | Tumour necrosis factor, alpha-induced protein 3 |
| 202687_s_at | TNFSF10 | 2·83 | 1·23 | 0·67 | 0·77 | Tumour necrosis factor (ligand) superfamily member 10 |
| 205599_at | TRAF1 | 2·25 | 1·32 | 0·68 | 0·61 | Tumour necrosis factor receptor-associated factor 1 |
| 202871_at | TRAF4 | 1·43 | 1·58 | 0·57 | 0·48 | Tumour necrosis factor receptor-associated factor 4 |
| 206366_x_at | XCL1 | 1·24 | 2·66 | 0·46 | 0·76 | Chemokine (C motif) ligand 1 |
| Signal transduction | ||||||
| 210538_s_at | AIP1 | 1·35 | 1·54 | 0·65 | 0·61 | Baculoviral IAP repeat-containing 3 |
| 209369_at | ANXA3 | 1·39 | 6·82 | 0·61 | 0·05 | Annexin A3 |
| 1554343_a_at | BRDG1 | 1·45 | 1·67 | 0·52 | 0·55 | BCR downstream signalling 1 |
| 225946_at | C12orf2 | 3·20 | 1·77 | 0·23 | 0·23 | Ras association (RaIGDS/AF-6) domain family 8 |
| 204392_at | CAMK1 | 1·26 | 1·62 | 0·74 | 0·54 | Calcium/calmodulin-dependent protein kinase I |
| 231042_s_at | CAMK2D | 1·31 | 1·63 | 0·25 | 0·69 | Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta |
| 205692_s_at | CD38 | 1·37 | 1·29 | 0·71 | 0·48 | CD38 antigen (p45) |
| 231747_at | CYSLTR1 | 3·16 | 1·45 | 0·55 | 0·43 | Cysteinyl leukotriene receptor 1 |
| 211272_s_at | DGKA | 1·43 | 1·23 | 0·77 | 0·54 | Diacylglycerol kinase alpha 80 kDa |
| 200762_at | DPYSL2 | 1·35 | 1·40 | 0·37 | 0·65 | Dihydropyrimtdinase-like 2 |
| 208370_s_at | DSCR1 | 1·23 | 1·90 | 0·63 | 0·77 | Down syndrome critical region gene 1 |
| 204794_at | DUSP2 | 1·55 | 2·57 | 0·39 | 0·45 | Dual specificity phosphatase 2 |
| 204015_s_at | DUSP4 | 1·35 | 2·66 | 0·65 | 0·39 | Dual specificity phosphatase 4 |
| 211333_s_at | FASLG | 1·20 | 1·37 | 0·49 | 0·80 | Fas ligand (TNF superfamily, member 6) |
| 211535_s_at | FGFR1 | 1·23 | 2·79 | 0·70 | 0·77 | Fibroblast growth factor receptor 1 |
| 224148_at | FYB | 1·50 | 1·21 | 0·45 | 0·79 | FYN binding protein (FYB-120/130) |
| 209304_x_at | GADD45B | 1·55 | 1·29 | 0·65 | 0·71 | Growth arrest and DNA-damage-inducible beta |
| 234284_at | GNG8 | 1·50 | 3·16 | 0·50 | 0·35 | Guanine nucleotide binding protein (G protein), gamma 8 |
| 224285_at | GPR174 | 1·91 | 1·42 | 0·56 | 0·58 | G protein-coupled receptor 174 |
| 223767_at | GPR84 | 4·41 | 1·44 | 0·05 | 0·56 | G protein-coupled receptor 84 |
| 211555_s_at | GUCY1B3 | 1·66 | 1·73 | 0·34 | 0·03 | Guanylate cyclase 1, soluble, beta 3 |
| 38037_at | HBEGF | 1·54 | 1·36 | 0·55 | 0·64 | Heparin-binding EGF-like growth factor |
| 203820_s_at | IMP-3 | 1·83 | 2·18 | 0·17 | 0·17 | IGF-II-mRNA-binding protein 3 |
| 203006_at | INPP5A | 1·40 | 1·86 | 0·60 | 0·52 | Inositol polyphosphate-5-phosphatase, 40 kDa |
| 231779_at | IRAK2 | 1·93 | 1·46 | 0·46 | 0·54 | Interleukin-1 receptor associated kinase 2 |
| 32137_at | JAG2 | 1·58 | 1·29 | 0·71 | 0·64 | Jagged 2 |
| 203904_x_at | KAI1 | 1·65 | 1·59 | 0·41 | 0·25 | CD82 antigen |
| 235252_at | KSR | 1·72 | 1·56 | 0·43 | 0·44 | Kinase suppressor of ras 1 |
| 210948_s_at | LEF1 | 1·21 | 1·64 | 0·41 | 0·79 | Hypothetical protein LOC641518 |
| 203236_s_at | LGALS9 | 1·48 | 1·27 | 0·73 | 0·51 | Lectin, galactoside-binding, soluble, 9 (galectin 9) |
| 220253_s_at | LRP12 | 1·27 | 1·30 | 0·31 | 0·73 | Low-density lipoprotein-related protein 12 |
| 206637_at | P2RY14 | 1·32 | 1·48 | 0·39 | 0·68 | Purinergic receptor P2Y, G-protein coupled, 14 |
| 210837_s_at | PDE4D | 1·35 | 1·31 | 0·62 | 0·69 | Phosphodiesterase 4D, cAMP-specific |
| 206726_at | PGDS | 6·45 | 1·40 | 0·60 | 0·43 | Prostaglandin D2 synthase, haematopoietic |
| 210617_at | PHEX | 1·53 | 4·08 | 0·21 | 0·47 | Phosphate regulating endopeptidase homologue, X-linked |
| 206370_at | PIK3CG | 1·23 | 1·32 | 0·50 | 0·77 | Phosphoinositide-3-kinase, catalytic, gamma polypeptide |
| 205632_s_at | PIP5K1B | 1·32 | 1·42 | 0·64 | 0·68 | Phosphalidylinositol-4-phosphate 5-kinase, type 1 beta |
| 215195_at | PRKCA | 2·17 | 1·36 | 0·64 | 0·61 | Protein kinase C, alpha |
| 210832_x_at | PTGER3 | 4·44 | 1·47 | 0·07 | 0·53 | Prostaglandin E receptor 3 (subtype EP3) |
| 1553535_a_at | RANGAP1 | 1·58 | 1·39 | 0·58 | 0·61 | Ran GTPase activating protein 1 |
| 234344_at | RAP2C | 1·75 | 1·26 | 0·46 | 0·74 | RAP2C, member of RAS oncogene family |
| 223809_at | RGS18 | 2·12 | 1·67 | 0·15 | 0·33 | Regulator of G-protein signalling 18 |
| 209882_at | RIT1 | 1·74 | 1·32 | 0·63 | 0·68 | Ras-like without CAAX 1 |
| 209451_at | TANK | 1·34 | 1·20 | 0·42 | 0·80 | TRAF family member-associated NFKB activator |
| 204924_at | TLR2 | 1·60 | 2·52 | 0·36 | 0·40 | Toll-like receptor 2 |
| 217979_at | TM4SF13 | 1·21 | 2·47 | 0·30 | 0·79 | Tetraspanin 13 |
| 209263_x_at | TM4SF7 | 2·05 | 1·41 | 0·58 | 0·59 | Tetraspanin 4 |
| Transcription | ||||||
| 1566989_at | ARID1B | 1·42 | 1·27 | 0·09 | 0·73 | AT-rich interactive domain 1B (SWIl-like) |
| 203973_s_at | CEBPD | 3·06 | 1·51 | 0·33 | 0·49 | CCAAT/enhancer binding protein (C/EBP), delta |
| 221598_s_at | CRSP8 | 1·60 | 1·29 | 0·71 | 0·68 | Cofactor required for Spl transcriptional activation, subunit 8, 34 kDa |
| 205249_at | EGR2 | 1·33 | 4·27 | 0·67 | 0·60 | Early growth response 2 (Krox-20 homologue, Drosophila) |
| 206115_at | EGR3 | 1·31 | 6·15 | 0·69 | 0·48 | Early growth response 3 |
| 201328_at | ETS2 | 1·57 | 1·72 | 0·43 | 0·40 | V-ets erythroblastosis virus E26 oncogene homologue 2 (avian) |
| 218810_at | FLJ23231 | 2·13 | 1·37 | 0·63 | 0·63 | Zinc finger CCCH-type containing 12A |
| 209189_at | FOS | 21·56 | 1·31 | 0·13 | 0·69 | V-fos FBJ murine osteosarcoma viral oncogene homologue |
| 223408_s_at | FOXK2 | 2·26 | 1·22 | 0·48 | 0·78 | Forkhead box K2 |
| 202723_s_at | FOXO1A | 1·47 | 1·27 | 0·57 | 0·73 | Forkhead box O1A (rhabdomyosarcoma) |
| 224211_at | FOXP3 | 1·62 | 1·41 | 0·59 | 0·23 | Forkhead box P3 |
| 207156_at | HIST1H2AG | 1·73 | 1·30 | 0·41 | 0·70 | Histone 1, H2ag |
| 220042_x_at | HIVEP3 | 1·26 | 1·65 | 0·74 | 0·56 | Human immunodeficiency virus type I enhancer binding protein 3 |
| 207826_s_at | ID3 | 1·34 | 8·64 | 0·60 | 0·66 | Inhibitor of DNA binding 3, dominant negative helix-loop-hetix protein |
| 204549_at | IKBKE | 2·33 | 1·29 | 0·71 | 0·66 | Inhibitor of kappa light polypeptide gene enhancer in B cells |
| 219878_s_at | KLF13 | 1·89 | 1·26 | 0·34 | 0·74 | Kruppel-like factor 13 |
| 207667_s_at | MAP2K3 | 1·33 | 1·28 | 0·72 | 0·57 | Mitogen-activated protein kinase kinase 3 |
| 201502_s_at | NFKBIA | 2·31 | 1·29 | 0·71 | 0·57 | Nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor |
| 222105_s_at | NKIRAS2 | 1·84 | 1·21 | 0·69 | 0·79 | NFKB inhibitor interacting Ras-like 2 |
| 204622_x_at | NR4A2 | 1·35 | 4·31 | 0·65 | 0·63 | Nuclear receptor subfamily 4, group A, member 2 |
| 207978_s_at | NR4A3 | 1·33 | 3·53 | 0·62 | 0·67 | Nuclear receptor subfamily 4, group A, member 3 |
| 202600_s_at | NRIPI | 1·86 | 1·39 | 0·26 | 0·61 | Nuclear receptor interacting protein 1 |
| 216841_s_at | SOD2 | 1·25 | 1·73 | 0·36 | 0·75 | Superoxide dismutase 2, mitochondrial |
| 201416_at | SOX4 | 1·53 | 2·21 | 0·47 | 0·38 | SRY (sex determining region Y)-box 4 |
| 223635_s_at | SSBP3 | 2·12 | 1·25 | 0·75 | 0·62 | Single-stranded DNA binding protein 3 |
| 206506_s_at | SUPT3H | 1·47 | 1·31 | 0·57 | 0·69 | Suppressor of Ty 3 homologue (S. cerevisiae) |
| 221618_s_at | TAF9L | 1·25 | 1·49 | 0·47 | 0·75 | TAF9-like RNA polymerase II |
| 203177_x_at | TFAM | 1·63 | 1·23 | 0·77 | 0·57 | Transcription factor A, mitochondrial |
| 213943_at | TWIST1 | 1·89 | 3·14 | 0·04 | 0·11 | Twist homologue 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) |
| 219836_at | ZBED2 | 1·33 | 4·76 | 0·67 | 0·21 | Zinc finger, BED-type containing 2 |
| 211965_at | ZFP36L1 | 2·02 | 1·47 | 0·29 | 0·53 | Zinc finger protein 36, C3H type-like 1 |
| 230760_at | ZFY | 1·41 | 1·25 | 0·75 | 0·02 | Zinc finger protein, Y-linked |
| 228854_at | ZNF145 | 3·26 | 1·21 | 0·40 | 0·79 | Transcribed locus |
| 235121_at | ZNF542 | 2·68 | 1·33 | 0·63 | 0·67 | Zinc finger protein 542 |