Figure 1.

Immunomodulatory effect of cyclooxygenase (COX) inhibition on tumour cell line-mediated suppression of cytosine–phosphate–guanosine (CpG) oligodesoxynucleotide (ODN)-activated plasmacytoid dendritic cell (PDC)-derived interferon-α (IFN-α) secretion. PDC were pre-incubated with medium or with supernatants (1 : 1) from tumour cell lines PCI-0 and FADU treated with or without indomethacin before stimulation with CpG ODN 2216 for 24 hr. IFN-α production was measured using enzyme-linked immunosorbent assays (ELISAs). The mean values ± standard error of the mean (SEM) of three individual experiments are shown. P*[Medium/FADU] = 0·04.