. Author manuscript; available in PMC: 2010 May 1.

Published in final edited form as: Kidney Int. 2009 Feb 18;75(9):936–944. doi: 10.1038/ki.2009.9

Table 1.

Effect of treatment on systolic blood pressure, electrolytes, and renal function

	Sham (n=5)	Uninephrectomy (n=7)	Uninephrectomy+ spironolactone (n=6)	Uninephrectomy+ FAD286 (n=6)	Uninephrectomy+ Ang II (n=7)	Uninephrectomy+ Ang II+spironolactone (n=6)	Uninephrectomy+ Ang II+FAD286 (n=7)
SBP (mm Hg)	157.7±2.7	168.0±2.4^*	159.1±2.2	162.9±2.5	172.2±2.5^*	171.7±2.5^*	167.4±2.4^*
Serum Na⁺(mmol/l)	137.3±0.5 (N=4)	138.4±1.1	137.6±2.2 (N=5)	138.2±2.6	138.7±2.2	140.8±3.6^*,^‡ (N=4)	138.3±1.3 (N=4)
Serum K⁺(mmol/l)	5.6±0.6	5.1±0.2	5.9±0.3^†	5.5±0.3	5.3±0.3	5.40±.2	5.5±0.1
pH	7.47±0.03 (N=4)	7.43±0.04 (N=4)	7.46±0.05 (N=5)	7.42±0.07 (N=5)	7.44±0.07 (N=6)	7.44±0.03 (N=3)	7.38±0.06^*^‡(N=6)
HCO₃	26.6±2.2 (N=4)	28.8±2.9 (N=4)	28.0±1.6 (N=4)	26.9±2.5 (N=4)	27.1±1.6 (N=4)	27.7±0.3 (N=4)	27.0±2.7 (N=4)
BUN (mg/100 ml)	22.5±2.1	24.9±2.0	26.6±1.1	26.2±1.9	46.7±8.0^*,^†,^‡,^§,^\|\|,^¶	23.8±0.9	30.8±0.6
Urine K⁺ (mmol/l)	132±29	92±25	72±14	80±18	58±14	67±18	95±23
Urine Na⁺ (mmol/l)	245±44	221±31	269±23	243±49	205±66	214±83	275±115
Urine volume (ml)	22.2±4.8	45.6±17.2^*	48.0±4.0^*	47.0±10.6^*	56.0±11.0^*	48.8±14.3^*	53.3±38.2^*
Urine Na⁺/K⁺	2.0±0.2	3.1±0.4	4.3±0.6^*	3.4±0.4	4.2±1.8^*	3.7±1.0^*	4.1±2.2^*
Urine albumin/Cr (μg/mg)	460±226	1027±407	314±114	1062±488	3583±1606^*	2621±1074	2537±1694

Ang II, angiotensin II; Bun, blood urea nitrogen; SBP, systolic blood pressure.

P < 0.05 versus sham,

^†

P < 0.05 versus uninephrectomy,

^‡

P < 0.05 versus uninephrectomy+spironolactone,

^§

P < 0.05 versus uninephrectomy+FAD286,

^||

P < 0.05 versus uninephrectomy+Ang II+spironolactone,

^¶

P < 0.05 versus uninephrectomy+Ang II+FAD286.